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Survival benefit of exenteration in COVID-19-associated rhino-orbital mucormycosis.
Raj, Amit; Singh, Prabhakar; Sadhukhan, Kaushik; Chandra, Bhawesh; Kranti, Bhavana; Kumar, Subhash; Sinha, Upasna; Kokkayil, Pratyusha; Bhadani, Punam Prasad; Sinha, Prerna; Sanepalli, Sravani; Tiwari, Pragati; Nanda, Jayadev.
Afiliación
  • Raj A; Department of Ophthalmology, AIIMS, Patna, Bihar, India.
  • Singh P; Department of Ophthalmology, AIIMS, Patna, Bihar, India.
  • Sadhukhan K; Department of Ophthalmology, AIIMS, Patna, Bihar, India.
  • Chandra B; Department of Ophthalmology, AIIMS, Patna, Bihar, India.
  • Kranti B; Department of Otolaryngology and Head and Neck Surgery, AIIMS, Patna, Bihar, India.
  • Kumar S; Department of Radiodiagnosis, AIIMS, Patna, Bihar, India.
  • Sinha U; Department of Radiodiagnosis, AIIMS, Patna, Bihar, India.
  • Kokkayil P; Department of Microbiology, AIIMS, Patna, Bihar, India.
  • Bhadani PP; Department of Pathology, AIIMS, Patna, Bihar, India.
  • Sinha P; Department of Otolaryngology and Head and Neck Surgery, AIIMS, Patna, Bihar, India.
  • Sanepalli S; Department of Otolaryngology and Head and Neck Surgery, AIIMS, Patna, Bihar, India.
  • Tiwari P; Department of Otolaryngology and Head and Neck Surgery, AIIMS, Patna, Bihar, India.
  • Nanda J; Department of Otolaryngology and Head and Neck Surgery, AIIMS, Patna, Bihar, India.
Indian J Ophthalmol ; 72(2): 190-194, 2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38099361
ABSTRACT

PURPOSE:

There has been a sudden increase in the number of rhino-orbital mucormycosis cases, primarily affecting patients recovering from COVID-19 infection. The local health authorities have declared the current situation an epidemic. In this study, we assess the role of exenteration in preventing disease progression and improving survival in patients with rhino-orbital mucormycosis.

METHODS:

The patients undergoing exenteration were grouped into the exenteration arm and those denying exenteration were grouped into the nonexenteration arm. The patients were followed at 1 month and 3 months. The 6-month survival data were collected telephonically. Continuous data were presented as Mean ± SD/Median (IQR) depending on the normality distribution of data, whereas the frequency with percentages was used to present the categorical variables. Kaplan-Meier survival curves were created to estimate the difference in survival of patients with exenteration in rhino-orbital mucormycosis versus those without exenteration.

RESULTS:

A total of 14 patients were recruited for our study based on the inclusion and exclusion criteria. All the patients were qualified for exenteration; however, only eight patients underwent exenteration and six patients did not consent to exenteration. At the end of 3 months in the exenteration group, four (50%) patients died. Two patients died within a week of exenteration, whereas two patients died after 2 weeks of exenteration. The deaths in the first week were attributed to septic shock and the deaths happening beyond 2 weeks were attributed to severe meningitis. The Kaplan-Meier survival analysis showed the cumulative probability of being alive at 1 month in the exenteration arm to be 85%, and it decreased to 67% by 53 days and subsequently remained stable until the end of 3 months.

CONCLUSION:

The Kaplan-Meier survival analysis did not show a survival benefit of exenteration at 3 months and 6 months in COVID-associated rhino-orbital mucormycosis.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Orbitales / Infecciones Fúngicas del Ojo / Oftalmopatías / COVID-19 / Mucormicosis Límite: Humans Idioma: En Revista: Indian J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Orbitales / Infecciones Fúngicas del Ojo / Oftalmopatías / COVID-19 / Mucormicosis Límite: Humans Idioma: En Revista: Indian J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: India
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