Stereoselective Control of the Cu Activation of ß,ß-Diboryl Acrylates for Allylic Coupling Protocols with Concomitant Lactonization.
Org Lett
; 26(14): 2821-2826, 2024 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-38101420
ABSTRACT
The key to a successful C-B activation is to discriminate between two geminal boryl moieties that are exposed to the same reaction conditions. Here we describe a stereoselective C-B activation of ß,ß-diboryl acrylates forming exclusively the (Z)-α-borylalkenyl copper(I) key intermediate, for subsequent allylic alkylation reactions. The new borylated (Z)-skipped dienoates followed a feasible iodo-lactonization sequence for the preparation of borylated lactone cores, which can be used in drug discovery.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
España