Microglial APOE4: more is less and less is more.
Mol Neurodegener
; 18(1): 99, 2023 Dec 19.
Article
en En
| MEDLINE
| ID: mdl-38115077
ABSTRACT
Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer's disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have employed complementary gain-of-function and loss-of-function approaches to provide critical new insight into the impact of microglial APOE on AD pathogenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apolipoproteína E4
/
Enfermedad de Alzheimer
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Neurodegener
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos