Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis.

Akcakavak, Gokhan; Kazak, Filiz; Karatas, Ozhan; Alakus, Halil; Alakus, Ibrahim; Kirgiz, Omer; Celik, Zeynep; Yilmaz Deveci, Mehmet Zeki; Ozdemir, Ozgur; Tuzcu, Mehmet

Akcakavak, Gokhan; Kazak, Filiz; Karatas, Ozhan; Alakus, Halil; Alakus, Ibrahim; Kirgiz, Omer; Celik, Zeynep; Yilmaz Deveci, Mehmet Zeki; Ozdemir, Ozgur; Tuzcu, Mehmet.

Afiliación

Akcakavak G; Department of Pathology, Yozgat Bozok University, Yozgat, Turkey.
Kazak F; Department of Biochemistry, Hatay Mustafa Kemal University, Hatay, Turkey.
Karatas O; Department of Pathology, Cumhuriyet University, Sivas, Turkey.
Alakus H; Department of Surgery Hatay Mustafa Kemal University, Hatay, Turkey.
Alakus I; Department of Surgery Hatay Mustafa Kemal University, Hatay, Turkey.
Kirgiz O; Department of Surgery Hatay Mustafa Kemal University, Hatay, Turkey.
Celik Z; Department of Pathology, Selcuk University, Konya, Turkey.
Yilmaz Deveci MZ; Department of Surgery Hatay Mustafa Kemal University, Hatay, Turkey.
Ozdemir O; Department of Pathology, Selcuk University, Konya, Turkey.
Tuzcu M; Department of Pathology, Selcuk University, Konya, Turkey.

Toxicol Mech Methods ; 34(4): 413-422, 2024 May.

Article en En | MEDLINE | ID: mdl-38115227

Asunto(s)

Gentamicinas; FN-kappa B; Ratas; Animales; FN-kappa B/metabolismo; Gentamicinas/toxicidad; Eucaliptol/metabolismo; Eucaliptol/farmacología; Eucaliptol/uso terapéutico; Caspasa 3/metabolismo; Factor 2 Relacionado con NF-E2/genética; Factor 2 Relacionado con NF-E2/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Riñón; Estrés Oxidativo; Antioxidantes/metabolismo; Inflamación/metabolismo; Antiinflamatorios/farmacología; Antiinflamatorios/uso terapéutico; Apoptosis

Palabras clave

Gentamicin; apoptosis; eucalyptol; inflammation; nephrotoxicity; oxidative stress

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gentamicinas / FN-kappa B Límite: Animals Idioma: En Revista: Toxicol Mech Methods Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido

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