[First clinical and oncological experiences with triplet therapy for high-volume metastatic hormone-sensitive prostate cancer]. / Erste klinische und onkologische Erfahrungen mit der Triplet-Therapie beim "high-volume" metastasierten hormonsensiblen Prostatakarzinom.
Urologie
; 63(3): 254-261, 2024 Mar.
Article
en De
| MEDLINE
| ID: mdl-38127147
ABSTRACT
BACKGROUND:
Treatment with androgen deprivation therapy (ADT) plus extended hormone therapy (ARTA) is the standard of care for metastatic hormone-sensitive prostate cancer (mHSPC). Recent data of triplet combination therapies of ADTâ¯+ ARTA (abiraterone/darolutamide)â¯+ docetaxel chemotherapy showed a survival advantage for specific mHSPC patient subgroups.PURPOSE:
What treatment response is observed in real-world mHSPC setting using triplet combination therapy and what are the expected side effects?RESULTS:
All patients receiving triplet combination therapy of ADTâ¯+ ARTA (abiraterone/darolutamide)â¯+ docetaxel were included in the current study. A total of 14 patients with a median age of 62 years and 10/14 abiraterone or 4/14 darolutamide therapy could be included. The median PSA before initiation of therapy was 77â¯ng/ml (IQR 44-150). Overall, 86% of patients had a PSA response >â¯90% and the median PSA nadir was 0.3â¯ng/ml. Severe adverse events (grade III) during triplet therapy occurred in two patients (35,7%) with respectively febrile neutropenia 7.1% (1/14) and diarrhea with infection 7.1%. Other low grade adverse events (grade I/II) consisted of polyneuropathy (1/14), mucositis (1/14), xerostomia (1/14), weight loss (1/14) and fatigue (3/14) were detected. Chemotherapy was interrupted in one patient due to adverse events. After a median follow-up of ten months (IQR 7-17), two patients (14.2%) showed progression to castration resistance.CONCLUSION:
Triplet therapy shows a very good PSA response in clinical practice. Adverse events during therapy are mainly triggered by classical chemotherapy-known side effects.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
Límite:
Humans
/
Male
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Middle aged
Idioma:
De
Revista:
Die Urologie (Heidelberg. Online)
/
Urologie
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Alemania