Alpha 2-Macroglobulin Polymorphisms and Susceptibility to Alzheimer's Disease: A Comprehensive Meta-Analysis Based on 62 Studies.
J Alzheimers Dis Rep
; 7(1): 1351-1370, 2023.
Article
en En
| MEDLINE
| ID: mdl-38143774
ABSTRACT
Background:
The relationship between alpha 2-macroglobulin (A2M) gene and Alzheimer's disease (AD) has been widely studied across populations; however, the results are inconsistent.Objective:
This study aimed to evaluate the association of A2M gene with AD by the application of meta-analysis.Methods:
Relevant studies were identified by comprehensive searches. The quality of each study was assessed using the Newcastle-Ottawa Scale. Allele and genotype frequencies were extracted from each of the included studies. Odds ratio (OR) with corresponding 95% confidence intervals (CI) was calculated using a random-effects or fixed-effects model. The Cochran Q statistic and I2 metric was used to evaluate heterogeneity, and Egger's test and Funnel plot were used to assess publication bias.Results:
A total of 62 studies were identified and included in the current meta-analysis. The G allele of rs226380 reduced AD risk (OR 0.64, 95% CI 0.47-0.87, pFDRâ=â0.012), but carrier with the TT genotype was more likely to develop AD in Asian populations (OR 1.56, 95% CI 1.12-2.19, pFDRâ=â0.0135). The V allele of the A2M-I/V (rs669) increased susceptibility to AD in female population (OR, 95% CI 2.15, 1.38-3.35, pFDRâ=â0.0024); however, the II genotype could be a protective factor in these populations (OR, 95% CI 0.43, 0.26-0.73, pFDRâ=â0.003). Sensitivity analyses confirmed the reliability of the original results.Conclusions:
Existing evidence indicate that A2M single nucleotide polymorphisms (SNPs) may be associated with AD risk in sub-populations. Future studies with larger sample sizes will be necessary to confirm the results.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Systematic_reviews
Idioma:
En
Revista:
J Alzheimers Dis Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
China