Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes.
Alzheimers Dement
; 20(3): 1851-1867, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38146099
ABSTRACT
INTRODUCTION:
In this study, we leverage proteomic techniques to identify communities of proteins underlying Alzheimer's disease (AD) risk among clinically unimpaired (CU) older adults.METHODS:
We constructed a protein co-expression network using 3869 cerebrospinal fluid (CSF) proteins quantified by SomaLogic, Inc., in a cohort of participants along the AD clinical spectrum. We then replicated this network in an independent cohort of CU older adults and related these modules to clinically-relevant outcomes.RESULTS:
We discovered modules enriched for phosphorylation and ubiquitination that were associated with abnormal amyloid status, as well as p-tau181 (M4 ß = 2.44, p < 0.001, M7 ß = 2.57, p < 0.001) and executive function performance (M4 ß = -2.00, p = 0.005, M7 ß = -2.39, p < 0.001).DISCUSSION:
In leveraging CSF proteomic data from individuals spanning the clinical spectrum of AD, we highlight the importance of post-translational modifications for early cognitive and pathological changes.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Alzheimer
/
Disfunción Cognitiva
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Alzheimers Dement
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos