Plants Causing Toxic Myopathies.
Vet Clin North Am Equine Pract
; 40(1): 45-59, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38151404
ABSTRACT
Boxelder and sycamore maple contain hypoglycin A (HGA), the toxic metabolite of which, MCPA-CoA, inhibits fatty acid ß-oxidation, causing seasonal pasture myopathy (SPM) or atypical myopathy (AM), respectively. White snakeroot and rayless goldenrod contain multiple benzofuran ketones (BFKs). The identity/toxicity of BFKs appear variable, possibly involving interactions between toxins/toxic metabolites, but ultimately inhibit cellular energy metabolism. Unthrifty horses grazing sparse pastures during the fall appear predisposed to these plant-associated, frequently fatal, toxic myopathies. Toxidromes are characterized by varying degrees of rhabdomyolysis and cardiac myonecrosis, with plant toxins remaining toxic in hay and being excreted in milk.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Intoxicación por Plantas
/
Enfermedades de los Caballos
/
Enfermedades Musculares
Límite:
Animals
Idioma:
En
Revista:
Vet Clin North Am Equine Pract
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2024
Tipo del documento:
Article