Correlation between changes in serum YKL-40, LXRs, PPM1A, and TGF-ß1 levels and airway remodeling and lung function in patients with bronchial asthma.
J Asthma
; 61(7): 698-706, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38164946
ABSTRACT
OBJECTIVE:
This study investigates the correlation between serum levels of YKL-40, LXRs, PPM1A, and TGF-ß1 and airway remodeling and lung function in bronchial asthma patients.METHODS:
The study involved 80 bronchial asthma patients and 92 healthy individuals. Serum cytokines, airway remodeling, and lung function markers were compared across mild, moderate, and severe asthma cases using high-resolution CT, t-tests, ANOVA, and Pearson correlation analysis.RESULTS:
Asthmatic patients exhibited higher levels of serum YKL-40, LXRα, LXRß, TGF-ß1, airway wall thickness (T)/outer diameter (D), and WA% of total cross-sectional area compared to controls. Conversely, their serum PPM1A, Peak Expiratory Flow (PEF), and Forced Expiratory Volume in 1 s (FEV1) were lower. Serum YKL-40 and TGF-ß1 levels were positively correlated with T/D and WA%, and negatively correlated with PEF and FEV1. PPM1A levels were strongly associated with T/D, WA%, PEF, and FEV1.CONCLUSION:
The severity of bronchial asthma is associated with increased serum levels of YKL-40, LXRα, LXRß, and TGF-ß1 and decreased PPM1A. The levels of YKL-40, PPM1A, and TGF-ß1 have a significant correlation with airway remodeling and lung function.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Función Respiratoria
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Asma
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Factor de Crecimiento Transformador beta1
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Remodelación de las Vías Aéreas (Respiratorias)
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Proteína Fosfatasa 2C
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Proteína 1 Similar a Quitinasa-3
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Receptores X del Hígado
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Asthma
Año:
2024
Tipo del documento:
Article