Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis - a multicentre study.
Front Immunol
; 14: 1327947, 2023.
Article
en En
| MEDLINE
| ID: mdl-38169789
ABSTRACT
Background:
Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS).Objective:
To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB).Methods:
Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation.Results:
A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients.Conclusion:
κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esclerosis Múltiple Crónica Progresiva
/
Esclerosis Múltiple
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Front Immunol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Suiza