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Nitric Oxide-Releasing Porous Coating with Antibacterial Activity and Blood Compatibility.
Hu, Haiping; Wang, Lijuan; Dou, Jie; Shang, Yushuang; Liu, Xu; Shen, Jian; Yuan, Jiang.
Afiliación
  • Hu H; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Wang L; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Dou J; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Shang Y; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Liu X; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Shen J; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
  • Yuan J; National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
Langmuir ; 40(2): 1286-1294, 2024 01 16.
Article en En | MEDLINE | ID: mdl-38171006
ABSTRACT
Nitric oxide (NO)-releasing coating is promising to enhance the biocompatibility of medical devices. In this study, polyurethane (PU) and S-nitrosated keratin (KSNO) were dissolved with dimethyl sulfoxide (DMSO) and tetrahydrofuran (THF) to prepare a coating solution. This solution is facile to form a porous coating on various substrates based on solvent-evaporation-induced phase separation (SEIPS). The coating could continuously release NO up to 200 h in the presence of ascorbic acid (Asc). In addition, the coating could accelerate endothelialization by promoting the viability of human umbilical vein endothelial cells (HUVECs) while inhibiting the proliferation of human umbilical artery smooth muscle cells (HUASMCs). Furthermore, the coating had good antibacterial activity and blood compatibility. Taken together, this universal coating provides wider potential applications in the field of cardiovascular implants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antibacterianos / Óxido Nítrico Límite: Humans Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antibacterianos / Óxido Nítrico Límite: Humans Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article