Biological Immune Mechanism of Retina.
Front Biosci (Landmark Ed)
; 28(12): 363, 2023 12 29.
Article
en En
| MEDLINE
| ID: mdl-38179761
ABSTRACT
The blood-retinal barrier (BRB) is a well-recognized mechanism that underlies the retina's immunological privilege. The BRB is formed locally by inhibitory molecules that bind to cell membranes, as well as by the suppression of systemic immune responses. Recent studies have revealed that microglial cells are essential for maintaining immunological privilege within the retina by regulating the immune response. They achieve this by enhancing or reducing ocular inflammation. Furthermore, retinal pigment epithelium (RPE) regulates the behavior of immune cells within the retina, which can lead microglial cells to reduce inflammation and promote immunological tolerance. With the aim of better understanding the biology of immunological processes within the retina, this article reviews the BRB and discusses the factors, systemic immune responses, microglia, RPE, and their associated enzymes that enable the BRB.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retina
/
Epitelio Pigmentado de la Retina
Límite:
Humans
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Año:
2023
Tipo del documento:
Article
País de afiliación:
China