C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018-2023).
Bioorg Chem
; 143: 107091, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38183683
ABSTRACT
This scientific review documents the recent progress of C3-spirooxindoles chemistry (synthesis and reaction mechanism) and their bioactivities, focusing on the promising results as well as highlighting the biological mechanism via the reported molecular docking findings of the most bioactive derivatives. C3-Spirooxindoles are attractive bioactive agents and have been found in a variety of natural compounds, including alkaloids. They are widely investigated in the field of medicinal chemistry and play a key role in medication development, such as antivirals, anticancer agents, antimicrobials, etc. Regarding organic synthesis, several traditional and advanced strategies have been reported, particularly those that started with isatin derivatives.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Espiro
/
Benzopiranos
/
Espirooxindoles
/
Nitrilos
Idioma:
En
Revista:
Bioorg Chem
/
Bioorganic chem
/
Bioorganic chemistry
Año:
2024
Tipo del documento:
Article
País de afiliación:
Arabia Saudita
Pais de publicación:
Estados Unidos