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Brazilin-Ce nanoparticles attenuate inflammation by de/anti-phosphorylation of IKKß.
Li, Shengxuan; Wang, Kun; Jiang, Kai; Xing, Dongmei; Deng, Ruhua; Xu, Yue; Ding, Yue; Guan, Huida; Chen, Lin-Lin; Wang, Dandan; Chen, Yang; Bu, Wenbo; Xiang, Yaozu.
Afiliación
  • Li S; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Wang K; Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
  • Jiang K; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Xing D; The First Affiliated Hospital of Henan University of Chinese Medicine, Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, Zhengzhou, 450000, Henan, China.
  • Deng R; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Xu Y; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Ding Y; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
  • Guan H; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
  • Chen LL; Key Laboratory of Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, China.
  • Wang D; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
  • Chen Y; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, School of Life Sciences and Technology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. Electronic address: chenyanglg@tongji.edu.cn.
  • Bu W; Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China. Electronic address: wbbu@fudan.edu.cn.
  • Xiang Y; State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, School of Life Sciences and Technology, Shanghai Fourth People's Hospital, Tongji
Biomaterials ; 305: 122466, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38184960
ABSTRACT
Inflammation is associated with a series of diseases like cancer, cardiovascular disease and infection, and phosphorylation/dephosphorylation modification of proteins are important in inflammation regulation. Here we designed and synthesized a novel Brazilin-Ce nanoparticle (BX-Ce NPs) using Brazilin, which has been used for anti-inflammation in cardiovascular diseases but with narrow therapeutic window, and Cerium (IV), a lanthanide which has the general activity in catalyzing the hydrolysis of phosphoester bonds, to conferring de/anti-phosphorylation of IKKß. We found that BX-Ce NPs specifically bound to Asn225 and Lys428 of IKKß and inhibited its phosphorylation at Ser181, contributing to appreciably anti-inflammatory effect in cellulo (IC50 = 2.5 µM). In vivo mouse models of myocardial infarction and sepsis also showed that the BX-Ce NPs significantly ameliorated myocardial injury and improved survival in mice with experimental sepsis through downregulating phosphorylation of IKKß. These findings provided insights for developing metal nanoparticles for guided ion interfere therapy, particularly synergistically target de/anti-phosphorylation as promising therapeutic agents for inflammation and related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzopiranos / Cerio / Sepsis / Nanopartículas / Nanopartículas del Metal Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Biomaterials Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzopiranos / Cerio / Sepsis / Nanopartículas / Nanopartículas del Metal Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Biomaterials Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos