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CBr4 as a Mild Oxidant-Enabled Oxidation of a sp3 C-H Bond: A Facile Synthesis of the Persistent Iminium Salts of Tetrahydroisoquinolines.
Chen, Yuqin; Zhang, Shuwei; Li, Yuemei; Li, Tong; Ma, Qiyuan; Yuan, Yu; Jia, Xiaodong.
Afiliación
  • Chen Y; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Zhang S; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Li Y; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Li T; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Ma Q; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Yuan Y; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
  • Jia X; School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, Jiangsu, China, 225002.
Chemistry ; 30(14): e202303952, 2024 Mar 07.
Article en En | MEDLINE | ID: mdl-38193608
ABSTRACT
Using CBr4 as a mild oxidant, the direct C-H bond oxidation of N-aryltetrahydroisoquinolines was achieved, giving a series of the corresponding iminium salts in high yields under metal- and photo-free reaction conditions. This reaction is superior in high yields and good functional group tolerance, and the late-stage derivatization showed that these iminium salts can readily be applied to the synthesis of the functionalized THIQs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Alemania