Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13.
J Antibiot (Tokyo)
; 77(3): 189-192, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38200162
ABSTRACT
A novel antibiotic biosynthetic precursor of cezomycin, named precezomycin (1), was isolated from culture broth of actinomycete Kitasatospora putterlickiae 10-13. The planar structure was determined by 1D/2D NMR and HR(ESI)MS data analyses, and the absolute configurations were established by TDDFT calculation of ECD spectra. Precezomycin (1) exhibited moderate antibacterial activity against gram-positive bacteria including Staphylococcus aureus and Bacillus subtilis. The discovery of 1 extends the natural product family of cezomycin and provides a new insight into understanding the biosynthetic process of these polyether ionophore metabolites.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Streptomycetaceae
/
Calcimicina
/
Actinobacteria
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China