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Aurora B promotes the CENP-T-CENP-W interaction to guide accurate chromosome segregation in mitosis.
Liu, Wei; Dou, Zhen; Wang, Chunyue; Zhao, Gangyin; Wu, Fengge; Wang, Chunli; Aikhionbare, Felix; Ye, Mingliang; Sedzro, Divine Mensah; Yang, Zhenye; Fu, Chuanhai; Wang, Zhikai; Gao, Xinjiao; Yao, Xuebiao; Song, Xiaoyu; Liu, Xing.
Afiliación
  • Liu W; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Dou Z; Keck Center for Cellular Dynamics and Organoids Plasticity, Atlanta, GA 30310, USA.
  • Wang C; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Zhao G; Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Hefei 230026, China.
  • Wu F; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Wang C; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Aikhionbare F; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Ye M; National Chromatographic Research and Analysis Center, Chinese Academy of Sciences, Dalian 116023, China.
  • Sedzro DM; Keck Center for Cellular Dynamics and Organoids Plasticity, Atlanta, GA 30310, USA.
  • Yang Z; National Chromatographic Research and Analysis Center, Chinese Academy of Sciences, Dalian 116023, China.
  • Fu C; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Wang Z; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Gao X; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Yao X; MOE Key Laboratory for Cellular Dynamics, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, University of Science and Technology of China School of Life Sciences, Hefei 230027, China.
  • Song X; Keck Center for Cellular Dynamics and Organoids Plasticity, Atlanta, GA 30310, USA.
  • Liu X; Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Hefei 230026, China.
J Mol Cell Biol ; 16(2)2024 Jul 29.
Article en En | MEDLINE | ID: mdl-38200711
ABSTRACT
Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle microtubules. Centromeres are captured by individual microtubules via a kinetochore constitutive centromere-associated network (CCAN) during chromosome segregation. CCAN contains 16 subunits, including CENP-W and CENP-T. However, the molecular recognition and mitotic regulation of the CCAN assembly remain elusive. Here, we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of CENP-T. Aurora B phosphorylates CENP-W at threonine 60, which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in mitosis. These findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Segregación Cromosómica / Aurora Quinasa B / Mitosis Límite: Humans Idioma: En Revista: J Mol Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Cromosómicas no Histona / Segregación Cromosómica / Aurora Quinasa B / Mitosis Límite: Humans Idioma: En Revista: J Mol Cell Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China