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Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer.
Damaskos, Christos; Psilopatis, Iason; Garmpi, Anna; Dimitroulis, Dimitrios; Nikolettos, Konstantinos; Vrettou, Kleio; Sarantis, Panagiotis; Koustas, Evangelos; Kouraklis, Gregory; Antoniou, Efstathios A; Karamouzis, Michail V; Nikolettos, Nikolaos; Tsikouras, Panagiotis; Marinos, Georgios; Kontomanolis, Emmanouil; Kontzoglou, Konstantinos; Garmpis, Nikolaos.
Afiliación
  • Damaskos C; Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece.
  • Psilopatis I; N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Garmpi A; Department of Obstetrics and Gynecology, University Erlangen, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
  • Dimitroulis D; First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Nikolettos K; Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Vrettou K; Department of of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Sarantis P; Department of Cytopathology, Sismanogleio General Hospital, 15126 Athens, Greece.
  • Koustas E; Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Kouraklis G; Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Antoniou EA; Department of Surgery, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Karamouzis MV; N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Nikolettos N; Department of General Surgery and HPB Surgery of Adults and Children, Hygeia Hospital, 15123 Athens, Greece.
  • Tsikouras P; Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Marinos G; Department of of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Kontomanolis E; Department of of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
  • Kontzoglou K; Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Garmpis N; Department of of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Cancers (Basel) ; 16(1)2024 Jan 01.
Article en En | MEDLINE | ID: mdl-38201636
ABSTRACT
BACKGROUND/

AIM:

Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer. MATERIALS AND

METHODS:

A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients.

RESULTS:

Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer.

CONCLUSIONS:

High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Grecia