The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes.
Arch Biochem Biophys
; 752: 109883, 2024 02.
Article
en En
| MEDLINE
| ID: mdl-38211638
ABSTRACT
Free fatty acids, like palmitic acid (PA), and xanthophyll pigments, like lutein (LUT) are the natural membrane compounds in plants. To study the effect of PA on LUT and their organization, a model membrane of 1,2-dimyristoyl-sn-glycerol-3-phosphocholine (DMPC) enriched with 2 mol% PA and 1 mol% LUT was formed. Molecular mechanisms underlying the interaction between these two compounds were examined with application of molecular spectroscopy techniques, e.g., visible spectroscopy, electron paramagnetic resonance and Fourier transform infrared. We determined the monomeric/dimeric organization of LUT in the membrane. We proved that the presence of PA in the lipid phase facilitated and stabilized the formation of LUT structures in the membrane. Lutein with PA did not form strong molecular aggregates like H- and J-structures. We presented the simplified model membrane that could be a suitable representation of the physiological process of de-esterification of PA from LUT appearing in natural biomembranes in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Luteína
/
Xantófilas
Límite:
Humans
Idioma:
En
Revista:
Arch Biochem Biophys
/
Arch. biochem. biophys
/
Archives of biochemistry and biophysics
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos