Gene Expression Profile Class Change in a Case of Aggressive, Recurrent Melanoma.
J Vitreoretin Dis
; 8(1): 93-96, 2024.
Article
en En
| MEDLINE
| ID: mdl-38223774
ABSTRACT
Purpose:
To report a novel case of a recurrent melanoma that had a change in its genetic expression profile (GEP) class over a 2-year period.Methods:
This retrospective case study evaluated a patient with a recurrent uveal melanoma that changed classes from 1A to 1B.Results:
A large melanoma was first treated with brachytherapy, and during that time genetic testing revealed a class 1A tumor. Two years later the tumor was noted to be enlarging, and the patient elected for enucleation. Subsequent GEP showed a class 1B tumor.Conclusions:
An aggressive and large recurrent uveal melanoma that had changed from a class 1A to a class 1B tumor on subsequent GEP testing has never been reported before to our knowledge. It may imply that a recurrent or aggressive tumor has more mutations over time that could lead to a higher risk for metastasis. The natural course of a tumor's GEP class should be explored further.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Vitreoretin Dis
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos