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The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.
Lee, Jeong Han; Perez-Flores, Maria C; Park, Seojin; Kim, Hyo Jeong; Chen, Yingying; Kang, Mincheol; Kersigo, Jennifer; Choi, Jinsil; Thai, Phung N; Woltz, Ryan L; Perez-Flores, Dolores Columba; Perkins, Guy; Sihn, Choong-Ryoul; Trinh, Pauline; Zhang, Xiao-Dong; Sirish, Padmini; Dong, Yao; Feng, Wayne Wei; Pessah, Isaac N; Dixon, Rose E; Sokolowski, Bernd; Fritzsch, Bernd; Chiamvimonvat, Nipavan; Yamoah, Ebenezer N.
Afiliación
  • Lee JH; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Perez-Flores MC; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Park S; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Kim HJ; Prestige Biopharma, 11-12F, 44, Myongjigukje7-ro, Gangseo-gu, Busan, 67264, South Korea.
  • Chen Y; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Kang M; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Kersigo J; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Choi J; Prestige Biopharma, 11-12F, 44, Myongjigukje7-ro, Gangseo-gu, Busan, 67264, South Korea.
  • Thai PN; Department of Biology, University of Iowa, Iowa City, IA, USA.
  • Woltz RL; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Perez-Flores DC; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
  • Perkins G; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
  • Sihn CR; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Trinh P; National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, 92093, USA.
  • Zhang XD; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV, 89557, USA.
  • Sirish P; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
  • Dong Y; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
  • Feng WW; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA, 95616, USA.
  • Pessah IN; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.
  • Dixon RE; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.
  • Sokolowski B; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA, 95616, USA.
  • Fritzsch B; Department of Physiology & Membrane Biology, Tupper Hall, One Shields Avenue, Davis, CA, 95616, USA.
  • Chiamvimonvat N; Department of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
  • Yamoah EN; Department of Biology, University of Iowa, Iowa City, IA, USA.
Nat Commun ; 15(1): 526, 2024 Jan 16.
Article en En | MEDLINE | ID: mdl-38228630
ABSTRACT
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Ciliadas Auditivas Internas / Oído Interno Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Ciliadas Auditivas Internas / Oído Interno Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos