Association of Lipoprotein(a) with arterial stiffness: A Mendelian randomization study.
Eur J Clin Invest
; 54(5): e14168, 2024 May.
Article
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| MEDLINE
| ID: mdl-38239089
ABSTRACT
BACKGROUND:
In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV).METHODS:
Genetic variants associated with Lp(a) were retrieved from the UK Biobank GWAS (N = 290,497). A non- overlapping GWAS based on a European cohort (N = 7,000) was used to obtain genetic associations with PWV (outcome) and utilized two different measures for the same trait, brachial-ankle (baPWV) and carotid-femoral (cfPWV) PWV. We applied a two-sample MR using the inverse variance weighting method (IVW) and a series of sensitivity analyses for 170 SNPs that were selected as instrumental variables (IVs).RESULTS:
Our analyses do not support a causal association between Lp(a) and PWV for neither measurement [ßiwv(baPWV) = -.0005, p = .8 and ßiwv(cfPWV) = -.006, p = .16]. The above findings were consistent across sensitivity analyses including weighted median, mode-based estimation, MR-Egger regression and MR-PRESSO.CONCLUSION:
We did not find evidence indicating that Lp(a) is causally associated with PWV, the gold standard marker of arterial stiffness.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lipoproteína(a)
/
Rigidez Vascular
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Clin Invest
Año:
2024
Tipo del documento:
Article
País de afiliación:
Grecia