Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain.
Cell Signal
; 116: 111061, 2024 04.
Article
en En
| MEDLINE
| ID: mdl-38242270
ABSTRACT
Mitochondrial adaptation is important for stress resistance throughout life. Here we show that WDR23 loss results in an enrichment for genes regulated by nuclear respiratory factor 1 (NRF1), which coordinates mitochondrial biogenesis and respiratory functions, and an increased steady state level of several nuclear coded mitochondrial resident proteins in the brain. Wdr23KO also increases the endogenous levels of insulin degrading enzyme (IDE) and the relaxin-3 peptide (RLN3), both of which have established roles in mediating mitochondrial metabolic and oxidative stress responses. Taken together, these studies reveal an important role for WDR23 as a component of the mitochondrial homeostat in the murine brain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Proteostasis
Límite:
Animals
Idioma:
En
Revista:
Cell Signal
Año:
2024
Tipo del documento:
Article