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Sex-specific differences in systemic immune responses in MIS-C children.
Rajamanickam, Anuradha; Kumar, Nathella Pavan; Venkataraman, Aishwarya; Varadarjan, Poovazhagi; Selladurai, Elilarasi; Sankaralingam, Thangavelu; Thiruvengadam, Kannan; Selvam, Ramya; Thimmaiah, Akshith; Natarajan, Suresh; Ramaswamy, Ganesh; Putlibai, Sulochana; Sadasivam, Kalaimaran; Sundaram, Balasubramanian; Hissar, Syed; Ranganathan, Uma Devi; Babu, Subash.
Afiliación
  • Rajamanickam A; National Institutes of Health-National Institute for Research in Tuberculosis - International Center for Excellence in Research, Chennai, India. anuradha@icerindia.org.
  • Kumar NP; National Institute for Research in Tuberculosis, Chennai, India.
  • Venkataraman A; National Institute for Research in Tuberculosis, Chennai, India.
  • Varadarjan P; Institute of Child Health and Hospital for Children, Chennai, India.
  • Selladurai E; Institute of Child Health and Hospital for Children, Chennai, India.
  • Sankaralingam T; Dr. Mehta's Children's Hospital, Chennai, India.
  • Thiruvengadam K; National Institute for Research in Tuberculosis, Chennai, India.
  • Selvam R; Dr. Mehta's Children's Hospital, Chennai, India.
  • Thimmaiah A; Dr. Mehta's Children's Hospital, Chennai, India.
  • Natarajan S; Rainbow Children's Hospital, Chennai, India.
  • Ramaswamy G; Rainbow Children's Hospital, Chennai, India.
  • Putlibai S; Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.
  • Sadasivam K; Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.
  • Sundaram B; Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.
  • Hissar S; National Institute for Research in Tuberculosis, Chennai, India.
  • Ranganathan UD; National Institute for Research in Tuberculosis, Chennai, India.
  • Babu S; National Institutes of Health-National Institute for Research in Tuberculosis - International Center for Excellence in Research, Chennai, India.
Sci Rep ; 14(1): 1720, 2024 01 19.
Article en En | MEDLINE | ID: mdl-38243064
ABSTRACT
Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare manifestation of Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection that can result in increased morbidity and mortality. Mounting evidence describes sex disparities in the clinical outcomes of coronavirus disease 2019 (COVID-19). However, there is a lack of information on sex-specific differences in immune responses in MIS-C. This study is an observational and cross-sectional study and we wanted to examine immune parameters such as cytokines, chemokines, acute phase proteins (APPs), growth factors, microbial translocation markers (MTMs), complement components and matrix metalloproteinases (MMPs) in MIS-C children, based on sex. Male children were associated with heightened levels of pro-inflammatory cytokines-IFNγ, IL-2, TNFα, IL-1α, IL-1ß, IL-6, IL-12, G-CSF and GM-CSF, chemokines-CCL2, CCL11, CXCL1, CXCL8 and CXCL10, acute phase proteins-α-2M, CRP, growth factors VEGF and TGFα, microbial translocation markers- iFABP, LBP, EndoCAb, complement components-C1q, MBL and C3 and matrix metalloproteinases MMP-8 and MMP-9 compared to female children with MIS-C. These results indicate that the heightened immune response in males is a characteristic feature of MIS-C. These findings might explain the differential disease pathogenesis in males compared to females with MIS-C and facilitate a deeper understanding of this disease.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / SARS-CoV-2 / COVID-19 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: India