Pathways driving tendinopathy and enthesitis: siblings or distant cousins in musculoskeletal medicine?
Lancet Rheumatol
; 5(5): e293-e304, 2023 May.
Article
en En
| MEDLINE
| ID: mdl-38251592
ABSTRACT
Tendinopathy and enthesitis share clinical, anatomical, and molecular parallels. However, their relationship is complex, presenting challenges in diagnosis and treatment. The biomechanics underlying these pathologies, together with relative immune and stromal contributions to pathology, are characterised by crucial comparative elements. However, methodologies used to study enthesitis and tendinopathy have been divergent, which could account for discrepancies in how these conditions are perceived and treated. In this Review, we summarise key clinical parallels between these two common presentations in musculoskeletal medicine and address factors that currently preclude development of more effective therapeutics. Furthermore, we describe molecular similarities and disparities that govern pathological mechanisms in tendinopathy and enthesitis, thus informing translational studies and treatment strategies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Musculoesqueléticas
/
Tendinopatía
/
Entesopatía
/
Medicina
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Lancet Rheumatol
Año:
2023
Tipo del documento:
Article
Pais de publicación:
Reino Unido