Characterizing a new tool to manipulate area postrema GLP1R+ neurons across species.
Physiol Behav
; 276: 114474, 2024 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-38272107
ABSTRACT
Nausea is an uncomfortable sensation that accompanies many therapeutics, especially diabetes treatments involving glucagon-like peptide-1 receptor (GLP1R) agonists. Recent studies in mice have revealed that GLP1R-expressing neurons in the area postrema play critical roles in nausea. Here, we characterized a ligand-conjugated saporin that can efficiently ablate GLP1R+ cells from humans, mice, and the Suncus murinus, a small animal model capable of emesis. This new tool provides a strategy to manipulate specific neural pathways in the area postrema in the Suncus murinus and may help elucidate roles of area postrema GLP1R+ neurons in emesis during therapeutics involving GLP1R agonists.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Área Postrema
/
Receptor del Péptido 1 Similar al Glucagón
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Physiol Behav
Año:
2024
Tipo del documento:
Article
País de afiliación:
Panamá