Inpatient Complications and Outcomes for Burn Patients Admitted With Methamphetamine Intoxication.
J Burn Care Res
; 45(4): 1026-1031, 2024 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-38285638
ABSTRACT
Methamphetamine intoxication frequently complicates inpatient burn admissions. While single-institution studies describe adverse outcomes during resuscitation, little is known about the risks of amphetamine intoxication on inpatient complications and perioperative management. The US National Trauma Data Bank was queried for burn encounters between 2017 and 2021. Amphetamine intoxication was identified on admission. Primary outcomes included death, stroke, and myocardial infarction (MI). Secondary outcomes included organ failure and surgical management. Multivariable regressions modeled outcomes adjusting for available covariates including demographics, TBSA burned, and inhalation injury. Bonferroni adjustments were applied. Our study identified a total of 73,968 primary burn encounters with toxicology screens. Among these, 800 cases (1.1%) were found to have positive methamphetamine drug screens upon admission. Methamphetamine users were significantly older (41.7 vs 34.9 years, Pâ
<â
.001), had a greater percentage of males (69.6 vs 65.4, Pâ
=â
.045), were more likely to have inhalation injury (Pâ
<â
.001), and had larger %TBSA burns (16% vs 13%, Pâ
<â
.001). Methamphetamine users were no more likely to die, experience MI, or experience stroke during admission. In contrast, methamphetamine users were significantly more likely to have alcohol withdrawal (Pâ
=â
.019), acute kidney injury (AKI) (Pâ
<â
.001), deep vein thrombosis (Pâ
=â
.001), pulmonary embolism (PE) (Pâ
=â
.039), sepsis (Pâ
=â
.026), and longer intensive care unit (ICU) stays (Pâ
<â
.001). Methamphetamine use was associated with a longer number of days to the first procedure (Pâ
=â
.005). Of all patients who required surgery (15.0%), methamphetamine users required significantly more total debridements and reconstructive procedures (Pâ
<â
.001). While not associated with mortality, methamphetamine intoxication was associated with an increased risk of many complications including PE, deep vein thrombosis, AKI, sepsis, and longer ICU stays. Methamphetamine intoxication was associated with delays in surgical care.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quemaduras
/
Metanfetamina
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Burn Care Res
/
J. brun care res
/
Journal of burn care and research
Asunto de la revista:
TRAUMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido