Real-world implementation of a multilevel interventions program to prevent mother-to-child transmission of HBV in China.
Nat Med
; 30(2): 455-462, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38297093
ABSTRACT
Reducing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is a fundamental step toward the HBV elimination goal. The multicentred, multilevel SHIELD program aimed to use an intense intervention package to reduce HBV MTCT in China. This study was conducted in diverse health settings across China, encompassing 30,109 pregnant women from 178 hospitals, part of the interim analysis of stage II of the SHIELD program, and 8,642 pregnant women from 160 community-level health facilities in stage III of the SHIELD program. The study found that the overall MTCT rate was 0.23% (39 of 16,908; 95% confidence interval (CI) 0.16-0.32%) in stage II and 0.23% (12 of 5,290; 95% CI 0.12-0.40%) in stage III. The MTCT rate was lower among participants who were compliant with the interventions (stage II 0.16% (95% CI 0.10-0.26%); stage III 0.03% (95% CI 0.00-0.19%)) than among those who were noncompliant (3.16% (95% CI 1.94-4.85%); 1.91% (95% CI 0.83-3.73%); P < 0.001). Our findings demonstrate that the comprehensive interventions among HBV-infected pregnant women were feasible and effective in dramatically reducing MTCT.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Hepatitis B
Tipo de estudio:
Sysrev_observational_studies
Aspecto:
Implementation_research
Límite:
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China