Nuclear α-synuclein regulates transcription and affects neuronal differentiation.
FEBS J
; 291(9): 1886-1888, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38297983
ABSTRACT
α-Synuclein is a member of the synuclein family well known for its involvement in Parkinson's disease and other synucleinopathies. Most studies investigate the mechanism of its involvement in pathology within the cell cytoplasm and extracellular space. However, despite a continuing interest in α-synuclein, two questions about this protein remain poorly understood. What is the normal physiological function of α-synuclein, and what does it do in the cell nucleus? A recent article by Takaaki Nakamura and colleagues contains at least a partial answer to both questions. The authors identified previously unknown α-synuclein-interacting proteins in the nucleus and showed that the protein complex containing α-synuclein modulates transcriptional profiles controlling the process of epigenetic alterations and neural differentiation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transcripción Genética
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Núcleo Celular
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Alfa-Sinucleína
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Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS J
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido