Suppression of Sleeping Beauty-induced Gliomagenicity in Ts1Cje Mice, a Model of Down Syndrome.
Anticancer Res
; 44(2): 489-495, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38307564
ABSTRACT
BACKGROUND/AIM:
Individuals with Down syndrome (DS), attributed to triplication of human chromosome 21 (Hsa21), exhibit a reduced incidence of solid tumors. However, the prevalence of glioblastoma among individuals with DS remains a contentious issue in epidemiological studies. Therefore, this study examined the gliomagenicity in Ts1Cje mice, a murine model of DS. MATERIALS ANDMETHODS:
We employed the Sleeping Beauty transposon system for the integration of human oncogenes into cells of the subventricular zone of neonatal mice.RESULTS:
Notably, Sleeping Beauty-mediated de novo murine gliomagenesis was significantly suppressed in Ts1Cje mice compared to wild-type mice. In glioblastomas of Ts1je mice, we observed an augmented presence of M1-polarized tumor-associated macrophages and microglia, known for their anti-tumor efficacy in the early stage of tumor development.CONCLUSION:
Our findings in a mouse model of DS offer novel perspectives on the diminished gliomagenicity observed in individuals with DS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Down
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2024
Tipo del documento:
Article
Pais de publicación:
GR
/
GRECIA
/
GREECE
/
GRÉCIA