Sex-related differences in Cushing's disease: a systematic review and meta-analysis.
Ann Saudi Med
; 44(1): 55-65, 2024.
Article
en En
| MEDLINE
| ID: mdl-38311874
ABSTRACT
BACKGROUND AND OBJECTIVES:
Cushing's disease is a rare endocrine disorder. This review aimed to examine sex-specific differences in Cushing's disease. DESIGN AND SETTINGS A meta-analysis was performed on published articles discussing the gender impact of Cushing's disease.METHODS:
A systematic search was conducted to identify studies from Medline, Embase, CENTRAL and Scopus. Nine studies enrolling 1047 patients diagnosed with Cushing's disease were included in this meta-analysis.RESULTS:
Male patients presented at a younger age (MD [mean difference]=-5.43; 95% CI [-5.78, -5.08]; P<.00001) than females. Male patients had a significantly higher prevalence of osteoporosis (RR [risk ratio]=1.75; 95% CI [1.36, 225]; P<.0001) and hypokalemia (RR=1.66; 95% CI [1.27, 2.16]; P=.0002). In addition, males had significantly higher rates of negative magnetic resonance imaging (RR=1.53; 95% CI [1.18, 2.0]; P=.002). No sex difference was observed in the prevalence of diabetes (RR=0.92; 95% CI [0.70, 1.22]); P=.57) and dyslipidemia (RR=1.33; 95% CI [0.88, 2.0]; P=.17).CONCLUSION:
Cushing's disease has a worse clinical presentation in males and more diagnostic difficulties compared to females.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ann Saudi Med
Asunto de la revista:
MEDICINA
Año:
2024
Tipo del documento:
Article