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Successful Osimertinib Rechallenge After Relapse Following Adjuvant Osimertinib: A Case Report.
Dwyer, Liam James; Singhal, Nimit; Yu, Bing; Kao, Steven.
Afiliación
  • Dwyer LJ; Department of Medical Oncology, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Central Clinical School, University of Sydney, Darlington, New South Wales, Australia. Electronic address: liamjames.dwyer@health.nsw.gov.au.
  • Singhal N; Cancer Centre, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Yu B; Central Clinical School, University of Sydney, Darlington, New South Wales, Australia; Department of Medical Genomics, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; NSW Health Pathology, Newcastle, New South Wales, Australia.
  • Kao S; Department of Medical Oncology, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia; Central Clinical School, University of Sydney, Darlington, New South Wales, Australia.
J Thorac Oncol ; 19(4): 650-652, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38340108
ABSTRACT
Adjuvant osimertinib represents a recent paradigm shift in the management of resected EGFR-mutated lung cancer. The optimal subsequent treatment of patients who relapse after completion of 3 years of adjuvant osimertinib is unknown. Here, we report two cases of complete response to osimertinib rechallenge after relapse from previous adjuvant osimertinib use, and a serial molecular panel exhibiting a lack of acquired resistance mechanisms. Future prospective studies are warranted to confirm the optimal treatment of patients who relapse after previous adjuvant osimertinib.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Acrilamidas / Carcinoma de Pulmón de Células no Pequeñas / Indoles / Neoplasias Pulmonares Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Thorac Oncol / J. thorac. oncol / Journal of thoracic oncology Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Acrilamidas / Carcinoma de Pulmón de Células no Pequeñas / Indoles / Neoplasias Pulmonares Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Thorac Oncol / J. thorac. oncol / Journal of thoracic oncology Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos