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Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women.
Rinaldi, Sabina; Dossus, Laure; Keski-Rahkonen, Pekka; Kiss, Agneta; Navionis, Anne-Sophie; Biessy, Carine; Travis, Ruth; Weiderpass, Elisabete; Romieu, Isabelle; Eriksen, Anne Kirstine; Tjonneland, Anne; Kvaskoff, Marina; Canonico, Marianne; Truong, Thérèse; Katzke, Verena; Kaaks, Rudolf; Catalano, Alberto; Panico, Salvatore; Masala, Giovanna; Tumino, Rosario; Lukic, Marko; Olsen, Karina Standahl; Zamora-Ros, Raul; Santiuste, Carmen; Aizpurua Atxega, Amaia; Guevara, Marcela; Rodriguez-Barranco, Miguel; Sandstrom, Maria; Hennings, Joakim; Almquist, Martin; Aglago Kouassivi, Elom; Christakoudi, Sofia; Gunter, Marc; Franceschi, Silvia.
Afiliación
  • Rinaldi S; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Dossus L; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Keski-Rahkonen P; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Kiss A; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Navionis AS; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Biessy C; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Travis R; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Weiderpass E; International Agency for Research on Cancer (IARC/WHO), Lyon, France.
  • Romieu I; Center for Research on Population Health, National Institute of Public Health, Mexico, Mexico.
  • Eriksen AK; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Tjonneland A; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Kvaskoff M; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • Canonico M; Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, CESP, Team "Exposome and Heredity", Villejuif, France.
  • Truong T; Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, CESP, Team "Exposome and Heredity", Villejuif, France.
  • Katzke V; Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, CESP, Team "Exposome and Heredity", Villejuif, France.
  • Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Catalano A; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Panico S; Department of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology and Public Health, University of Turin, Turin, Italy.
  • Masala G; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
  • Tumino R; Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
  • Lukic M; Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy.
  • Olsen KS; Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
  • Zamora-Ros R; Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway.
  • Santiuste C; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Aizpurua Atxega A; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
  • Guevara M; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
  • Rodriguez-Barranco M; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain.
  • Sandstrom M; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain.
  • Hennings J; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
  • Almquist M; Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain.
  • Aglago Kouassivi E; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
  • Christakoudi S; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
  • Gunter M; Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
  • Franceschi S; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Int J Cancer ; 154(12): 2064-2074, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38357914
ABSTRACT
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1 1.68, 95% CI 0.96-2.92, ptrend = .06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1 1.78, 95% CI 0.96-3.30, ptrend = .06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1 0.54, 95% CI 0.28-1.05, ptrend = .07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Adenocarcinoma Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Tiroides / Adenocarcinoma Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Int J Cancer Año: 2024 Tipo del documento: Article País de afiliación: Francia