Does maternal anxiety and depression increase the risk of asthma in the offspring? A systematic review and meta-analysis.
Eur Rev Med Pharmacol Sci
; 28(3): 1066-1076, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38375712
ABSTRACT
OBJECTIVE:
Adverse exposures during pregnancy have been linked with respiratory disorders in the offspring. Research also shows that maternal mental disorders can influence the risk of respiratory illnesses. We hereby systematically examined if specific mental disorders during pregnancy, namely, anxiety and depression, can increase the risk of asthma in the offspring. MATERIALS ANDMETHODS:
A literature search of PubMed, CENTRAL, Scopus, Embase, and Web of Science databases from inception to 15th October 2023 was undertaken for cohort studies assessing the association between maternal anxiety/depression and the risk of asthma in the offspring. Adjusted data was quantitatively synthesized in a random-effect meta-analysis model.RESULTS:
Nine studies with 1,027,469 mother-child pairs were included. Studies reported data on anxiety, depression, or both anxiety and depression. Maternal anxiety (OR 1.61 95% CI 1.29, 2.01 I2=0%), maternal depression (OR 1.25 95% CI 1.07, 1.45 I2=12%), and both combined (OR 1.28 95% CI 1.16, 1.41 I2=93%) were associated with significantly increase the risk of asthma in childhood. Overall, the pooled analysis showed that maternal anxiety or depression significantly increased the risk of asthma in childhood by 30% (OR 1.30 95% CI 1.20, 1.40 I2=75%). Results remained significant on multiple subgroup analyses.CONCLUSIONS:
Maternal anxiety and depression can increase the risk of asthma in childhood. The observational nature of studies, differences in adjusted founders, methodological variations, and predominance of European data are important limitations. Further prospective research taking into account present limitations is needed for improved evidence.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Asma
/
Depresión
Límite:
Child
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China