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Multiplexable and Scalable Aqueous Synthesis Platform for Oleate-Based, Bilayer-Coated Gold Nanoparticles.
Backhaus, Andreas; Albrecht, Jillian; Alzhanova, Gaukhar; Long, Avery; Arnold, Wyatt; Lee, Junseok; Tse, Ho-Yin; Su, Tina T; Cruz-Gomez, Sebastian; Lee, Seung Soo S; Menges, Fabian; Parent, Lucas R; Ratjen, Lars; Burtness, Barbara; Fortner, John D; Zimmerman, Julie B.
Afiliación
  • Backhaus A; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Albrecht J; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Alzhanova G; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Long A; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Arnold W; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Lee J; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Tse HY; Center for Green Chemistry and Green Engineering, Yale University, New Haven, CT, 06511, USA.
  • Su TT; Department of Immunology, Yale School of Medicine, New Haven, CT, 06511, USA.
  • Cruz-Gomez S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, 06511, USA.
  • Lee SSS; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Menges F; Department of Chemistry, Yale University, New Haven, CT, 06511, USA.
  • Parent LR; Innovation Partnership Building, University of Connecticut, Storrs, CT, 06269, USA.
  • Ratjen L; Center for Green Chemistry and Green Engineering, Yale University, New Haven, CT, 06511, USA.
  • Burtness B; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, 06511, USA.
  • Fortner JD; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
  • Zimmerman JB; Department of Chemical and Environmental Engineering, Yale University, 17 Hillhouse Avenue, Rm 530, New Haven, CT, 06511, USA.
Small ; 20(25): e2309919, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38377304
ABSTRACT
Despite gold-based nanomaterials having a unique role in nanomedicine, among other fields, synthesis limitations relating to reaction scale-up and control result in prohibitively high gold nanoparticle costs. In this work, a new preparation procedure for lipid bilayer-coated gold nanoparticles in water is presented, using sodium oleate as reductant and capping agent. The seed-free synthesis not only allows for size precision (8-30 nm) but also remarkable particle concentration (10 mm Au). These reaction efficiencies allow for multiplexing and reaction standardization in 96-well plates using conventional thermocyclers, in addition to simple particle purification via microcentrifugation. Such a multiplexing approach also enables detailed spectroscopic investigation of the nonlinear growth process and dynamic sodium oleate/oleic acid self-assembly. In addition to scalability (at gram-level), resulting gold nanoparticles are stable at physiological pH, in common cell culture media, and are autoclavable. To demonstrate the versatility and applicability of the reported method, a robust ligand exchange with thiolated polyethylene glycol analogues is also presented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Oléico / Nanopartículas del Metal / Oro Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Oléico / Nanopartículas del Metal / Oro Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania