Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus.

Zhao, Zhongchao; Chung, Young Hun; Steinmetz, Nicole F

Zhao, Zhongchao; Chung, Young Hun; Steinmetz, Nicole F.

Afiliación

Zhao Z; Department of NanoEngineering, University of California 9500 Gilman Dr, La Jolla San Diego CA 92093 USA nsteinmetz@ucsd.edu.
Chung YH; Center for Nano-ImmunoEngineering, University of California 9500 Gilman Dr, La Jolla San Diego CA 92093 USA.
Steinmetz NF; Moores Cancer Center, University of California 9500 Gilman Dr, La Jolla San Diego CA 92093 USA.

Mater Adv ; 5(4): 1473-1479, 2024 Feb 19.

Article en En | MEDLINE | ID: mdl-38380336

ABSTRACT

ABSTRACT

We have developed nanoparticle formulations targeting M2 macrophages for cancer immunotherapy by conjugating high-affinity binding peptides to cowpea mosaic virus as an immunostimulatory adjuvant. We confirmed the targeting of and uptake by M2 macrophages in vitro and the therapeutic efficacy of the nanoparticles against murine melanoma in vivo.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mater Adv Año: 2024 Tipo del documento: Article