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Direct Synthesis of Aryloxy Phosphonamidate Nucleotide Prodrugs Using the Cross Metathesis Assisted by Ultrasonic Irradiation.
Choi, Se Myeong; Nam, Ye Eun; An, Yeon Jin; Choi, Eun Rang; Park, Hyejin; Schinazi, Raymond F; Cho, Jong Hyun.
Afiliación
  • Choi SM; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.
  • Nam YE; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.
  • An YJ; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.
  • Choi ER; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.
  • Park H; Department of Translational Biomedical Sciences, Graduate School of Dong-A University, Busan 49201, Korea.
  • Schinazi RF; Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
  • Cho JH; Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea.
Org Lett ; 26(23): 4841-4846, 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38381649
ABSTRACT
A direct synthetic strategy of aryloxy phosphonamidate nucleotide prodrugs (A, G, C, and U) was developed with the CM reaction assisted by ultrasonic irradiation and partitioned addition of 12 mol % of Hoveyda-Grubbs (H-G) II catalyst in 61-82% yields as a mixture of E-/Z-isomers (∼21) from aryloxy vinylphosponamidate and 5'-vinyl nucleoside moieties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos