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The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study.
VanOrmer, Matthew; Thompson, Maranda; Thoene, Melissa; Riethoven, Jean-Jack; Natarajan, Sathish Kumar; Hanson, Corrine; Anderson-Berry, Ann.
Afiliación
  • VanOrmer M; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States of America.
  • Thompson M; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States of America.
  • Thoene M; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States of America.
  • Riethoven JJ; Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
  • Natarajan SK; Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States of America.
  • Hanson C; College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, United States of America.
  • Anderson-Berry A; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States of America.
PLoS One ; 19(2): e0297558, 2024.
Article en En | MEDLINE | ID: mdl-38381745
ABSTRACT

OBJECTIVE:

The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut microbiome.

METHODS:

After IRB approval, we collected stool specimens from 14 infants born <34 weeks gestation in the first, second, and fourth week of life to assess gut microbiome composition via 16S rRNA sequencing.

RESULTS:

We observed no significant differences in either phyla or key genera relative abundance between pre- and post-iron timepoints. We observed notable shifts in infant microbiome composition based on season of delivery.

CONCLUSION:

Though no obvious indication of iron-induced dysbiosis was observed in this unique study in the setting of prematurity, further investigation in a larger sample is warranted to fully understand iron's impact on the gastrointestinal milieu.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Microbioma Gastrointestinal Límite: Humans / Infant / Newborn Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Microbioma Gastrointestinal Límite: Humans / Infant / Newborn Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos