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Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea.
Kim, Hee Jin; Kim, Nayoung; Jang, Jae Young; Kim, Sihyun; Lee, Jongchan; Oh, Hyeon Jeong.
Afiliación
  • Kim HJ; Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.
  • Kim N; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Jang JY; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • Kim S; Department of Medical Device Development, Seoul National University College of Medicine, Seoul, Korea.
  • Lee J; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Oh HJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Gut Liver ; 2024 Feb 23.
Article en En | MEDLINE | ID: mdl-38388182
ABSTRACT
Background/

Aims:

The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex.

Methods:

Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system.

Results:

Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227).

Conclusions:

Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gut Liver Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gut Liver Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur