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Comparison between characteristics of immunoglobulin M nephropathy and other glomerular diseases.
Yun, Giae; Kwon, Eun Jeong; Park, Seokwoo; Jeong, Jong Cheol; Kim, Sejoong; Na, Ki Young; Chin, Ho Jun.
Afiliación
  • Yun G; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Kwon EJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Park S; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Jeong JC; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Kim S; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Na KY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  • Chin HJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Article en En | MEDLINE | ID: mdl-38389153
ABSTRACT

Background:

Immunoglobulin M (IgM) nephropathy (IgMN) is characterized by the IgM deposition in the kidney's mesangium. We assessed the impact of electron-dense deposits (EDDs) on IgMN and compared it to other kidney diseases.

Methods:

We enrolled 63 adult patients with IgMN who underwent renal biopsy from May 2003 to June 2017. We compared clinicopathological features of IgMN based on EDD presence; compared characteristics to 91 minimal change disease (MCD), 103 focal segmental glomerulosclerosis (FSGS), and 469 immunoglobulin A nephropathy (IgAN) patients. Renal events were defined as a >50% decrease in estimated glomerular filtration rate (eGFR), eGFR of <15 mL/min/1.73 m2, or end-stage renal disease development.

Results:

IgMN patients with EDDs had increased mesangial cellularity, matrix accumulation, prominent immunofluorescent staining, and more diffuse podocyte effacement than those without EDD. Clinical characteristics and renal outcomes did not differ significantly based on EDD presence. During 79.5 ± 58.8 months of follow-up, renal events developed in 46.2% and 46.0% of IgMN cases with and without EDD. IgMN (46.0%) and FSGS cases (40.8%) had similar frequencies of renal events and higher frequency than MCD (18.7%) or IgAN cases (26.4%). IgMN cases had more severe manifestations than MCD and IgAN; higher blood pressure, lower proteinuria, and eGFR levels at biopsy than MCD cases; higher blood pressure, proteinuria, frequency of acute kidney injury, and lower eGFR levels.

Conclusion:

Clinical characteristics of IgMN did not differ based on EDD presence. Therefore, IgMN should be defined based on IF findings. IgMN shared clinical characteristics with FSGS but had more severe than MCD and IgAN.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Kidney Res Clin Pract Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Kidney Res Clin Pract Año: 2024 Tipo del documento: Article Pais de publicación: Corea del Sur