The study of HMOX1 DNA methylation and gene expression and the diagnostic potential of miR-153-3p in preeclampsia.
Epigenomics
; 16(6): 389-401, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38410927
ABSTRACT
Background:
The objective was to elucidate the potential epigenetic regulatory mechanism in HMOX1 expression in preeclampsia. Materials &methods:
HMOX1 promoter DNA methylation was evaluated in the placental tissue and blood of preeclamptic and normotensive pregnant women. HMOX1 and miR-153-3p gene expression were assessed in placental tissue and peripheral blood mononuclear cells (PBMCs). Related microarray datasets in the Gene Expression Omnibus database were also analyzed.Results:
In placental tissue, despite HMOX1 expression downregulation, there was no significant change in HMOX1 methylation. In PBMCs, there was no significant alteration in HMOX1 expression, while hypomethylation was observed in blood. The miR-153-3p expression increased in the placental tissue and in the PBMCs of preeclampsia.Conclusion:
DNA methylation does not affect HMOX1 expression, while miR-153-3p might be a biomarker for preeclampsia.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
MicroARNs
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Epigenomics
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán