The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy.

ABSTRACT

Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroautophagy/autophagy and chaperoning of nascent proteins. Here, we explore the crosstalk between autophagy and the HSP90 chaperone in maintaining proteostasis, highlighting their interplay and significance in cellular homeostasis.Abbreviation HSP90 heat shock protein 90; PTMs post-translational modifications.