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Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors.
Zhang, Xu-Ze; Ma, Xiao-Dong; Wang, Wan-Ting; Peng, Fei; Hou, Ye-Mao; Shen, Yue-Xia; Sun, Yu-Qi; Chen, Jin-Fang; Yin, Yi-Jin; Zeng, Yu-Ye; Yu, Yi; Zhou, Peng; Zhang, Fu-Hao; He, Yan-Feng; Shen, Ying-Fang.
Afiliación
  • Zhang XZ; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China; Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Xining 810001, China; Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Com
  • Ma XD; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China; Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Commission, Qinghai Minzu University, Xining 810007, China.
  • Wang WT; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Peng F; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Hou YM; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Shen YX; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Sun YQ; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Chen JF; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Yin YJ; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Zeng YY; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Yu Y; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China.
  • Zhou P; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China; Qinghai Provincial Key Laboratory of Animal Ecological Genomics, Xining 810001, China.
  • Zhang FH; Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Commission, Qinghai Minzu University, Xining 810007, China; College of Pharmaceutical, Qinghai Minzu University, Xining 810007, China.
  • He YF; Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Commission, Qinghai Minzu University, Xining 810007, China; College of Pharmaceutical, Qinghai Minzu University, Xining 810007, China. Electronic address: hyfdqzdb@163.com.
  • Shen YF; College of Ecological Environment and Resources, Qinghai Minzu University, Xining 810007, China; Key Laboratory of Resource Chemistry and Eco-environmental Protection in Tibetan Plateau of State Ethnic Affairs Commission, Qinghai Minzu University, Xining 810007, China. Electronic address: syfnc@126.
Article en En | MEDLINE | ID: mdl-38412702
ABSTRACT
This study compares the skin structures of Rana kukunoris with two different skin colors living in the same area of Haibei in the Northeastern Qinghai-Tibet Plateau. The skin thickness of the khaki R. kukunoris was significantly greater than that of the brown R. kukunoris (P < 0.01), and significantly more mucous and granular glands were present on the dorsal skin of the khaki frog (P < 0.05). Meanwhile, the melanocytes on the dorsal skin of the brown frog were significantly larger than those on the khaki one (P < 0.05). Morphological changes in the expansion and aggregation of melanocytes seemed to deepen the skin color of R. kukunoris. Moreover, transcriptome sequencing identified tyrosine metabolism, melanogenesis, and riboflavin metabolism as the main pathways involved in melanin formation and metabolism in brown R. kukunoris. TYR, MC1R was upregulated as the skin color of R. kukunoris was deepened and contributed to melanin production and metabolism. In contrast, the khaki frog had significantly more upregulated genes and metabolic pathways related to autoimmunity. The khaki frog appeared to defend against ultraviolet (UV) radiation-induced damage by secreting mucus and small molecular peptides, whereas the brown frog protected itself by distributing a large amount of melanin. Hence, the different skin colors of R. kukunoris might represent different adaptation strategies for survival in the intense UV radiation environment of the Qinghai-Tibet Plateau.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ranidae / Piel / Pigmentación de la Piel / Transcriptoma Límite: Animals Idioma: En Revista: Comp Biochem Physiol Part D Genomics Proteomics Asunto de la revista: BIOLOGIA / GENETICA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ranidae / Piel / Pigmentación de la Piel / Transcriptoma Límite: Animals Idioma: En Revista: Comp Biochem Physiol Part D Genomics Proteomics Asunto de la revista: BIOLOGIA / GENETICA Año: 2024 Tipo del documento: Article