Survivin as a potential biomarker in the diagnosis of bladder cancer: A systematic review and meta-analysis.
Urol Oncol
; 42(5): 133-143, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38418270
ABSTRACT
Early detection, diagnosis, and treatment take on critical significance in preventing and treating bladder cancer. As indicated by numerous studies, survivin can serve as a biomarker of bladder cancer, whereas the results of a wide variety of studies have been controversial. This paper is to assess the accuracy of survivin in the diagnosis of bladder cancer by a meta-analysis. The studies regarding the diagnosis of bladder cancer using survivin were systematically retrieved from the CNKI, WanFang, CBM, VIP, Web of science, cochrane library and pubmed were extracted, and the literature quality was assessed. Meta-analysis was conducted using STATA 16.0 MP. 2,082 relevant studies were searched, and 40 studies were finally covered for meta-analysis. The pooled specificity and pooled sensitivity of survivin mRNA was 0.95 (95%CI 0.91, 0.97) and 0.94 (95%CI 0.88, 0.97). The pooled specificity and pooled sensitivity of survivin protein reached 0.95 (95%CI 0.90, 0.97) and 0.87 (95%CI 0.78, 0.92). The pooled positive likelihood ratio, pooled negative likelihood ratio, the area under the curve, and diagnostic odds ratio for survivin mRNA reached 17.7 (95%CI 10.3, 30.6), 0.07 (95%CI 0.04, 0.12), 0.98 (95%CI 0.97, 0.99) and 266 (95%CI 114, 621), respectively. For survivin protein was 16.4 (95%CI 7.9, 33.9), 0.14 (95%CI 0.08, 0.24), 0.97 (95%CI 0.95, 0.98) and 117 (95%CI 38, 357), respectively. Survivin takes on great significance in diagnosing bladder cancer. However, due to some limitations in the number and quality of covered studies, this conclusion should be validated through additional higher quality clinical studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Biomarcadores de Tumor
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Proteínas Inhibidoras de la Apoptosis
/
Survivin
Límite:
Humans
Idioma:
En
Revista:
Urol Oncol
Asunto de la revista:
NEOPLASIAS
/
UROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos