Generation of an induced pluripotent stem cell line (PNUYHi002-A) from a patient with Alzheimer's disease carrying PRNP M232R variant.
Stem Cell Res
; 76: 103361, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38437769
ABSTRACT
We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from a 59-year-old male patient with Alzheimer's disease (AD). The iPSC line was meticulously characterized to confirm its pluripotency, absence of transgenes, and normal karyotype. The unexpected discovery of the M232R variant in PRNP makes this cell line a valuable resource for investigating AD pathogenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Madre Pluripotentes Inducidas
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Enfermedad de Alzheimer
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Stem Cell Res
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido