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Association between neighborhood poverty and ovarian reserve: the ovarian aging study.
Pan, Anwesha; Crowder, Kyle D; Cedars, Marcelle I; Bleil, Maria E.
Afiliación
  • Pan A; From the Department of Anthropology, University of Washington, Seattle, WA.
  • Crowder KD; Department of Sociology, University of Washington, Seattle, WA.
  • Cedars MI; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA.
  • Bleil ME; Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, WA.
Menopause ; 31(5): 372-380, 2024 May 01.
Article en En | MEDLINE | ID: mdl-38442312
ABSTRACT

OBJECTIVE:

This study aimed to examine the association between neighborhood poverty and ovarian reserve.

METHODS:

Among 1,019 healthy premenopausal women in the Ovarian Aging Study, aggregate exposure to neighborhood poverty was examined in relation to biomarkers of ovarian reserve, antimüllerian hormone (AMH) and antral follicle count (AFC). Specifically, the interaction of age-x-neighborhood poverty was assessed cross-sectionally to determine whether AMH and AFC declines across women may be greater in women exposed to more neighborhood poverty. Neighborhood poverty was assessed by geocoding and linking women's residential addresses in adulthood to US Census data.

RESULTS:

Independent of covariates, a significant interaction term showed the association between age and AMH varied by degree of exposure to neighborhood poverty in adulthood ( b = -0.001, P < 0.05). AMH declines increased progressively across women exposed to low, medium, and high levels of neighborhood poverty. In addition, main effects showed that higher neighborhood poverty was related to higher AMH in the younger women only ( b = 0.022, P < 0.01). Results related to AFC were all nonsignificant ( P > 0.05).

CONCLUSIONS:

Across women, greater aggregate exposure to neighborhood poverty in adulthood was related to lower ovarian reserve, indexed by AMH. In addition, there was a positive association between neighborhood poverty and AMH in younger women that attenuated in the older women. Together, results suggest that neighborhood disadvantage may have detrimental impacts that manifest as initially higher AMH, resulting in greater ovarian follicle loss over time. However, it remains unclear whether these results examining differences across women may replicate when AMH declines by neighborhood poverty are examined longitudinally.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pobreza / Hormona Antimülleriana / Reserva Ovárica / Folículo Ovárico Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pobreza / Hormona Antimülleriana / Reserva Ovárica / Folículo Ovárico Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Menopause Asunto de la revista: GINECOLOGIA Año: 2024 Tipo del documento: Article
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