Omentin associates with serum metabolite profiles indicating lower diabetes risk: KORA F4 Study.
BMJ Open Diabetes Res Care
; 12(2)2024 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-38442989
ABSTRACT
INTRODUCTION:
Circulating omentin levels have been positively associated with insulin sensitivity. Although a role for adiponectin in this relationship has been suggested, underlying mechanisms remain elusive. In order to reveal the relationship between omentin and systemic metabolism, this study aimed to investigate associations of serum concentrations of omentin and metabolites. RESEARCH DESIGN ANDMETHODS:
This study is based on 1124 participants aged 61-82 years from the population-based KORA (Cooperative Health Research in the Region of Augsburg) F4 Study, for whom both serum omentin levels and metabolite concentration profiles were available. Associations were assessed with five multivariable regression models, which were stepwise adjusted for multiple potential confounders, including age, sex, body mass index, waist-to-hip ratio, lifestyle markers (physical activity, smoking behavior and alcohol consumption), serum adiponectin levels, high-density lipoprotein cholesterol, use of lipid-lowering or anti-inflammatory medication, history of myocardial infarction and stroke, homeostasis model assessment 2 of insulin resistance, diabetes status, and use of oral glucose-lowering medication and insulin.RESULTS:
Omentin levels significantly associated with multiple metabolites including amino acids, acylcarnitines, and lipids (eg, sphingomyelins and phosphatidylcholines (PCs)). Positive associations for several PCs, such as diacyl (PC aa C321) and alkyl-alkyl (PC ae C322), were significant in models 1-4, whereas those with hydroxytetradecenoylcarnitine (C141-OH) were significant in all five models. Omentin concentrations were negatively associated with several metabolite ratios, such as the valine-to-PC ae C322 and the serine-to-PC ae C322 ratios in most models.CONCLUSIONS:
Our results suggest that omentin may influence insulin sensitivity and diabetes risk by changing systemic lipid metabolism, but further mechanistic studies investigating effects of omentin on metabolism of insulin-sensitive tissues are needed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
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Citocinas
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Proteínas Ligadas a GPI
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Lectinas
Límite:
Humans
Idioma:
En
Revista:
BMJ Open Diabetes Res Care
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania