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The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.
Parkinson, Joanna; Sundell, Jesper; Rekic, Dinko; Nelander, Karin; Ericsson, Hans; Ebrahimi, Ahmad; Dota, Corina; Sunnåker, Mikael.
Afiliación
  • Parkinson J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Sundell J; Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
  • Rekic D; BioPharmaceuticals, Global Cardiovascular, Renal and Metabolic, AstraZeneca, Gothenburg, Sweden.
  • Nelander K; Late CVRM Biometrics, Late CVRM, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Ericsson H; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Ebrahimi A; Cardiovascular Safety Centre of Excellence, Global Patient Safety, Oncology R&D, AstraZeneca, Gothenburg, Sweden.
  • Dota C; Cardiovascular Safety Centre of Excellence, Global Patient Safety, Oncology R&D, AstraZeneca, Gothenburg, Sweden.
  • Sunnåker M; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Pharmacol Res Perspect ; 12(2): e1184, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38445541
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Peroxidasa Límite: Humans / Male Idioma: En Revista: Pharmacol Res Perspect Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Peroxidasa Límite: Humans / Male Idioma: En Revista: Pharmacol Res Perspect Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos