Effectiveness of glutamine and arginine in wound healing of pressure ulcers: A systematic review protocol.
J Tissue Viability
; 33(2): 239-242, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38448329
ABSTRACT
INTRODUCTION:
Various nutrients play a physiological role in the healing process of pressure ulcers (PUs). Nutritional interventions include the administration of enteral nutritional supplements and formulas containing arginine, glutamine, and micronutrients. The aim of this systematic review is to evaluate the effectiveness of enteral nutritional supplements and formulas containing arginine and glutamine on wound-related outcomes. These include (1) time to healing, (2) changes in wound size, (3) local wound infection, (4) PU recurrence, and (5) PU-related pain. MATERIALS ANDMETHODS:
This protocol was developed according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). A search will be conducted in the Cochrane Library, EMBASE, PubMed (MEDLINE), CINAHL (EBSCOhost interface) and Web of Science. In addition, a manual search will be conducted to identify relevant records. Except for systematic reviews, no restrictions will be placed on the study design, the population studied or the setting. Studies that do not address PUs, in vitro studies and studies that do not report wound-related outcomes will be excluded. Study selection, risk of bias assessment and data extraction will be performed independently by three researchers. Depending on the extent of heterogeneity of interventions, follow-up time and populations, results will be summarised either by meta-analysis or narrative synthesis.CONCLUSIONS:
This is the first systematic review to identify, evaluate and summarise the current evidence for enteral arginine and glutamine supplementation on wound-related outcomes in PUs. The review will provide a solid basis for deriving valid and clinically relevant conclusions in this area.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arginina
/
Cicatrización de Heridas
/
Úlcera por Presión
/
Revisiones Sistemáticas como Asunto
/
Glutamina
Límite:
Humans
Idioma:
En
Revista:
J Tissue Viability
Asunto de la revista:
ENFERMAGEM
/
FISIOLOGIA
Año:
2024
Tipo del documento:
Article