The role of Bach2 in regulating CD8 + T cell development and function.
Cell Commun Signal
; 22(1): 169, 2024 03 08.
Article
en En
| MEDLINE
| ID: mdl-38459508
ABSTRACT
Bach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately connected to CD8 + T lymphocytes in various differentiation states and subsets according to recent findings. Bach2 can regulate primitive T cells, stimulate the development and differentiation of memory CD8 + T cells, inhibit the differentiation of effector CD8 + T cells, and play a significant role in the exhaustion of CD8 + T cells. The appearance and development of diseases are tightly linked to irregular CD8 + T cell differentiation and function. Accordingly, Bach2 offers novel approaches and possible targets for the clinical treatment of associated disorders based on research on these pathways. Here, we summarize the role of Bach2 in the function and differentiation of CD8 + T cells and its potential clinical applications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Linfocitos T CD8-positivos
Límite:
Humans
Idioma:
En
Revista:
Cell Commun Signal
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido